ADULT- AND CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPARISON OF ONSET, CLINICAL FEATURES, SEROLOGY, AND OUTCOME
Identifieur interne : 002B23 ( Main/Exploration ); précédent : 002B22; suivant : 002B24ADULT- AND CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: A COMPARISON OF ONSET, CLINICAL FEATURES, SEROLOGY, AND OUTCOME
Auteurs : L. B. Tucker [États-Unis] ; S. Menon [Royaume-Uni] ; J. G. Schaller [États-Unis] ; D. A. Isenberg [Royaume-Uni]Source :
- Rheumatology [ 1462-0324 ] ; 1995.
Abstract
This study examines the differences which may distinguish systemic lupus erythematosus (SLE) presenting in adult life or childhood. A common database was established, with analysis of clinical, serological and outcome features of a cohert of patients with SLE, with disease diagnosed before the age of 16 (n = 39) or after the age of 16 (n = 165). Disease onset was generally more severe in the childhood-onset patients. Cardiopulmonary disease was more common in the older-onset group, but major haematological manifestations were more frequent in the childhood-onset group. Serologically, anti-DNA, anti-Sm and anti-RNP antibodies and a low C3 were all found more frequently in the younger patients. Twice as many adult-onset cases had died at the time of the last follow-up (10 vs 5%), but this group had been followed for a longer period (average 7.5 yr, S.D. 3.9 for adults vs average 4.8 yr, S.D. 3.2 for children). However, the younger patients were twice as likely (82 vs 40%) to require high-dose prednisone, although the requirement for immunosuppressive agents was similar in the two groups. Clinicians should anticipate that children with SLE have a more severe disease onset than adults in general.
Url:
DOI: 10.1093/rheumatology/34.9.866
Affiliations:
- Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Massachusetts
- Londres
- University College de Londres
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B." last="Tucker">L. B. Tucker</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pediatric Rheumatology, The Floating Hospital, New England Medical Center and Tufts University School of Medicine Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Correspondence to: L. B. Tucker, Division of Pediatric Rheumatology, Box 286, New England Medical Center, 750 Washington Street, Boston, MA 02111</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Menon, S" sort="Menon, S" uniqKey="Menon S" first="S." last="Menon">S. 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A common database was established, with analysis of clinical, serological and outcome features of a cohert of patients with SLE, with disease diagnosed before the age of 16 (n = 39) or after the age of 16 (n = 165). Disease onset was generally more severe in the childhood-onset patients. Cardiopulmonary disease was more common in the older-onset group, but major haematological manifestations were more frequent in the childhood-onset group. Serologically, anti-DNA, anti-Sm and anti-RNP antibodies and a low C3 were all found more frequently in the younger patients. Twice as many adult-onset cases had died at the time of the last follow-up (10 vs 5%), but this group had been followed for a longer period (average 7.5 yr, S.D. 3.9 for adults vs average 4.8 yr, S.D. 3.2 for children). However, the younger patients were twice as likely (82 vs 40%) to require high-dose prednisone, although the requirement for immunosuppressive agents was similar in the two groups. Clinicians should anticipate that children with SLE have a more severe disease onset than adults in general.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Massachusetts</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Tucker, L B" sort="Tucker, L B" uniqKey="Tucker L" first="L. B." last="Tucker">L. B. Tucker</name></region><name sortKey="Schaller, J G" sort="Schaller, J G" uniqKey="Schaller J" first="J. G." last="Schaller">J. G. Schaller</name><name sortKey="Tucker, L B" sort="Tucker, L B" uniqKey="Tucker L" first="L. B." last="Tucker">L. B. Tucker</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Menon, S" sort="Menon, S" uniqKey="Menon S" first="S." last="Menon">S. 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